George G Brownlee Selected Research

DNA-Directed RNA Polymerases (RNA Polymerase)

5/2010	Correlation between polymerase activity and pathogenicity in two duck H5N1 influenza viruses suggests that the polymerase contributes to pathogenicity.
7/2009	A quantitative strategy to detect changes in accessibility of protein regions to chemical modification on heterodimerization.
1/2009	The N-terminal region of the PA subunit of the RNA polymerase of influenza A/HongKong/156/97 (H5N1) influences promoter binding.
11/2006	Role of the influenza virus heterotrimeric RNA polymerase complex in the initiation of replication.
3/2006	A new promoter-binding site in the PB1 subunit of the influenza A virus polymerase.
5/2003	Two aromatic residues in the PB2 subunit of influenza A RNA polymerase are crucial for cap binding.
4/2003	A single amino acid mutation in the PA subunit of the influenza virus RNA polymerase promotes the generation of defective interfering RNAs.
7/2002	The RNA polymerase of influenza a virus is stabilized by interaction with its viral RNA promoter.

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George G Brownlee Research Topics

Disease

10	Human Influenza (Influenza) 05/2010 - 09/2002
3	Infections 07/2008 - 07/2002
1	Influenza in Birds (Avian Flu) 05/2010
1	Vaccinia 05/2003

Drug/Important Bio-Agent (IBA)

8	DNA-Directed RNA Polymerases (RNA Polymerase)IBA 05/2010 - 07/2002
3	Proteins (Proteins, Gene)FDA Link 01/2006 - 09/2002
2	Messenger RNA (mRNA)IBA 07/2008 - 09/2004
2	Complementary RNA (cRNA)IBA 07/2008 - 09/2004
2	Viral RNAIBA 09/2004 - 07/2002
1	Lysine (L-Lysine)FDA Link 07/2009
1	triphosphoric acid (triphosphate)IBA 07/2008
1	NucleosidesIBA 07/2008
1	RibonucleoproteinsIBA 07/2008
1	NucleoproteinsIBA 09/2004
1	Eukaryotic Initiation Factor-4EIBA 05/2003
1	Viral ProteinsIBA 05/2003
1	RNA Cap-Binding Proteins (Cap Binding Protein)IBA 05/2003
1	Amino Acids FDA Link 09/2002
1	Alanine (L-Alanine)FDA Link 09/2002
1	Histidine (L-Histidine)FDA Link 09/2002